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KMID : 0191119970120060532
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Journal of Korean Medical Science
1997 Volume.12 No. 6 p.532 ~ p.538
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Nitrous oxide synthase expression in placenta of preeclampsia
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Lee CN
Chang SW/Cho NH/Cho SH
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Abstract
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To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in
vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not
e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity
of the endothelial isoform of NOS expression in preeclampsia (n = 121) and normal (n = 14) pregnancies.
Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained
predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially
within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the
trophoblastic island or in the intravillous capillaries. The degree of e-NOS expression in pregnancy-induced
hypertension (PIH) was significantly lower than in normotensive placenta, and moreover in the patients
lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In
conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it
means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.
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